Henry Goldblatt, Developer of the Goldbatt Kidney : Mt Sinai Collection

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Goldblatt clamps for hypertension experiments, 1934

clamps_goldblatt-detail
Goldblatt’s clamps, one shown in placement tool.
Below instruments used to operate clamps.
clamps_goldgbatt-tools

Harry Goldblatt (1891-1977) received his M.D. from McGill University Medical School in 1916. He began a surgical residency, but when the U.S. entered the war he enlisted in the medical reserves of the U.S. army. He was sent to France and later Germany as an orthopedic specialist. He returned to Cleveland in 1924 as assistant professor of pathology at Western Reserve University School of Medicine, and in 1954 was appointed Professor of Experimental Pathology. In 1961 he was named emeritus, but in the same year was appointed director of the Louis D. Beaumont Memorial Research Laboratories at Mt. Sinai. He worked there until he retired in 1976. He died January 6, 1977.

Goldblatt’s interest in hypertension, sparked during his days as a surgical resident, eventually would lead to his international fame. During his early days in pathology, he noted persons with normal blood pressure who had systemic atherosclerosis (colloquially referred to as hardening of the arteries) that did not affect the kidney, and conversely patients with hypertension where arteriosclerosis was confined to the renal arteries. He had been taught that so-called benign essential hypertension was defined as persistent elevation of the blood pressure of unknown etiology, without significant impairment of the renal functions, and that the elevated blood pressure comes first and results in vascular sclerosis. In some cases renal damage does occur and may eventually lead to uremia. Goldblatt’s own observations; however, led him to believe that vascular sclerosis came first, followed by elevated blood pressure.

Testing this theory was difficult however, because Goldblatt did not know how to reproduce vascular sclerosis. He decided that simulating the results of obliterative renal vascular disease by constricting the arteries leading to the kidneys would be sufficient. In order to achieve constriction of the renal arteries, Goldblatt developed the clamps seen in the picture. His experiments using the clamps, performed on dogs, showed an increase in hypertension with no renal impairments. One of the earliest, unexpected findings was the constriction of one renal artery resulted in temporary elevation of blood pressure which returned to normal when the clamp was removed. Subsequent experiments by Goldblatt and others revealed that the constriction of the renal arteries causes a chemical chain reaction leading to hypertension. Renin, a substance released by the kidneys, is generated when the renal arteries are constricted. Renin in the bloodstream causes the production of angiotensin 1. Angiotensin 1 is benign until it reacts with the angiotensin converting enzyme (ACE) to become angiotensin 2, which is a major cause of hypertension.

Goldblatt, HarrryThe clamps built by Goldblatt initiated a chain reaction as well. Successive experiments and discoveries eventually led to the isolation of an ACE inhibitor. By preventing angiotensin 1 from becoming angiotensin 2, this inhibitor has reduced the risk of stroke, heart attack, and heart failure in many hypertension patients.

Goldblatt received many honors, most importantly the scientific achievement award of the A.M.A. in 1976. Because of the implications of his work, the American Heart Association established the Dr. Harry Goldblatt Fellowship. In 1957, to commemorate the 25 th anniversary of Goldblatt’s first successful experiment to induce arterial hypertension by renal ischemia in the dog, the University of Michigan held a conference on the basic mechanism of arterial hypertension at Ann Arbor. It was here that the confusion regarding the names of the various compounds was settled, and a universal nomenclature for angiotensin was accepted.

A forum discussion about healthcare in Northeast Ohio 1/16/2016

A forum discussion about healthcare in Northeast Ohio


Panelists (from left to right in video):
Sarah Hackenbracht, Executive Director, Cuyahoga Health Access Partnership
Dr. Todd Zeiger, Vice President, Primary Care Institute, University Hospitals
Heather Thiltgen, Senior VP, Medical Mutual

Moderator: Casey Ross, Healthcare Reporter, The Plain Dealer

Tuesday January 19, 2016 7-8:30pm
CWRU Siegal Facility in Beachwood, Ohio
This panel was consumer oriented and focused on accessing and affording health care at a time of rapid change in the industry–all with a Northeast Ohio focus. The panelists talked about changes in the way Cleveland area doctors are providing care and getting paid for care and how this affects patients.

The event cosponsors:
Case Western Reserve University Siegal Lifelong Learning Program, League of Women Voters-Greater Cleveland, Northeast Ohio Media Group

Corporate sponsor: First Interstate Properties, Ltd.

“How Reform is Changing Healthcare in Northeast Ohio: a Panel Discussion” (Video)

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“WHAT’S HONEST AND WHAT’S HYPE?”: HOW THE AFFORDABLE HEALTHCARE ACT
AND OTHER REFORMS WILL CHANGE HEALTHCARE IN NORTHEAST OHIO

March 19, 2014

Panel members include:
Dr. Eric Bieber, President, University Hospitals Accountable Care Organization
Dr. Akram Boutros, President and Chief Executive Officer, The MetroHealth System
Martin Hauser, Chief Executive Officer, SummaCare
Dr. David Longworth, Chairman of Medicine Institute, Cleveland Clinic
Moderated by Eileen Korey, former medical journalist

Presented by: 
CWRU Siegal Lifelong Learning, Teaching Cleveland Digital, and Cleveland Jewish News Foundation

Medicine in Cleveland by Diane Solov

Diane Solov is Program Manager of Better Health Greater Cleveland, a multi-stakeholder alliance dedicated to improving the quality of health care for people in Northeast Ohio with chronic illness. Based at Case Western Reserve University’s Center for Health Care Research and Policy at MetroHealth Medical Center, Solov manages the day-to-day operations of all aspects of the program.

Solov came to MetroHealth in March 2007 following a career in journalism, winning numerous awards and recognition for her work. She spent her last 15 years as a journalist at The Plain Dealer, Cleveland’s daily newspaper, as a medical editor, and previously, as a medical reporter. For nearly a decade, Solov often broke and edited stories about Northeast Ohio’s expansive health care market and national health care issues that affected them and their patients.

Solov earned a B.A. in anthropology from the University of Missouri and completed coursework in the M.A. program at its renowned School of Journalism. She was a 2010 Fellow of the Robert Wood Johnson Foundation’s Ladder to Leadership program.

The link is here

 

 

Healthcare/Medicine History in Cleveland

From the Encyclopedia of Cleveland

The link is here

MEDICINE. The development of medical care, science, and education in the Cleveland area, as a frontier community evolved into a major industrial center, is a microcosm of national developments in the U.S. The growth of the population and the financial resources available were determining factors. Although the CONNECTICUT LAND CO. commenced to sell its WESTERN RESERVE lands in 1796, it was not until 1800 that a young Connecticut physician, Moses Thompson (1776-1858), went west, cleared his land, and took up residence in what is today Hudson, OH. For 10 years he was the only physician in the Western Reserve west of Warren, OH. In 1810 DAVID LONG†, from Massachusetts, arrived in Cleveland, 25 miles north of Hudson on Lake Erie, a village of 57 inhabitants. A recent medical graduate, Long came because of the personal solicitation of a local resident who suggested that his income could be supplemented at first by teaching school and selling merchandise, a pattern common to undeveloped areas. Like PETER ALLEN† from Connecticut, who settled in Kinsman, OH, in 1808, Long and Thompson provided civic and cultural leadership in addition to medical care.

The completion of the OHIO AND ERIE CANAL in 1832 made the area more accessible, and by 1837 Cleveland had over 5,000 inhabitants, including 27 medical practitioners. By 1848 the population had doubled to more than 10,000, which quadrupled by 1860, with GERMANS and IRISH immigrants. The medical practitioners reflected the varieties of U.S. medical practice then available: regular physicians (allopaths), homeopaths (see HOMEOPATHY), botanics or Thompsonians, practitioners of electromagnetic medicine and mesmerism, and surgeon dentists (see DENTISTRY). They treated the wide spectrum of human ailments that prevailed in a prescientific medical world, in which the nature of disease was still poorly understood, and in which smallpox was the sole disease for which a preventive procedure, vaccination, was available. As emergencies arose, temporary hospitals (see HOSPITALS & HEALTH PLANNING) were set up, such as the army hospital created in 1813 at FORT HUNTINGTON in Cleveland to care for wounded soldiers of the War of 1812, and the hospital on WHISKEY ISLAND set up for the CHOLERA EPIDEMIC OF 1832. For most mild illness, people treated themselves with home remedies, often obtaining their information from popular medical books. Patent medicines, often very profitable, were widely advertised. Patients went to the doctor’s “shop” only for minor surgery, tooth extraction, and medicines compounded by the practitioner from drugs purchased in Pittsburgh or other larger cities to the east. House calls occupied much of the physician’s day, and often night, until well into the 20th century. Home delivery of infants was nearly universal until the 1920s.

In 1811, to regulate medical and surgical practice in Ohio, the state legislature set up medical districts for the purpose of creating local societies to certify and oversee practitioners. In 1824 the 19TH MEDICAL DISTRICT OF OHIO, comprising Cuyahoga and Medina counties, was designated; David Long was elected the first president. After a succession of name changes, in 1902 the present ACADEMY OF MEDICINE OF CLEVELAND of Cleveland emerged. Late in the 19th century, the state became the licensing agency for Ohio practitioners. The earliest permanent hospitals in the area were created as charitable institutions to care solely for the poor and the homeless. In 1836, when Cleveland, with a population of 4,800, incorporated as a city, the CLEVELAND BOARD OF HEALTH (est. 1832) erected a city infirmary, called City Hospital, the ancestor of Cleveland’s MetroHealth Medical Center.

Medical education quickly followed the population growth. In the early 19th century, most physicians were still educated as house students of practicing physicians; Moses Thompson in Hudson having been such a preceptor. But gradually medical colleges, chiefly proprietary institutions organized locally by enterprising physicians, spread throughout the country. The first in northeast Ohio was established at Willoughby, 15 miles from Cleveland, by a group of physicians who had migrated westward from New York State. Founded in 1834 as the Medical Department of Willoughby Univ. of Lake Erie, the school at first attracted outstanding teachers such as JOHN DELAMATER† (1787-1867) and JARED P. KIRTLAND† (1793-1877), but internal dissension led shortly to their resignation. They created a new school in Cleveland named the Cleveland Medical College. Originally chartered in 1843 as a department of the Western Reserve College of Hudson, this school existed in 1994 as the School of Medicine of CASE WESTERN RESERVE UNIVERSITY

Cleveland also became an educational center for homeopathic physicians, who began to settle in Ohio in the 1830s. In 1846 a homeopathic society was founded and a homeopathic pharmacy opened on PUBLIC SQUARE, and 4 years later the second school of homeopathy in the U.S., the Western College of Homeopathic Medicine, opened. The Cleveland Homeopathic Medical College, as it was later called, remained in existence from 1850 to 1914, when it became a division of Ohio State Univ. in Columbus. Since homeopathy attempted to reform the excesses of “regular” medical practices, opposing massive dosages and polypharmacy and advocating more conservative methods, regular physicians viewed it as heretical. The Cleveland homeopathic community in 1856 opened the first permanent hospital apart from the infirmary in the city. Named the CLEVELAND HOMEOPATHIC HOSPITAL, it treated mainly employees of RAILROADS who were sick or injured away from home. By 1879, since most other area hospitals would not admit homeopathic physicians or surgeons, a large new hospital, the antecedent of HURON RD. HOSPITAL in EAST CLEVELAND (which established the first NURSING training school west of the Alleghenies) was built on Huron Rd. Highly respected by the nonmedical community, a number of homeopathic physicians became community leaders, and at the turn of the 20th century, leading Cleveland citizens such as MARCUS A. HANNA†, MYRON T. HERRICK†, and JOHN D. ROCKEFELLER† supported their institutions.

In the 19th century, modern theories and practices of medicine began to emerge in Western Europe. The microscope revealed microorganisms that Louis Pasteur, Robert Koch, and others demonstrated to be disease-causing agents. It also revealed that the minute structure of the human body is composed of cells. In addition to the 2 new sciences of bacteriology (now microbiology) and cellular pathology, an innovation called anesthesia had been developed by American surgeons, and the English surgeon, Joseph Lister, had developed antiseptic surgical procedures. At the same time, a multitude of new chemical remedies appeared, produced by the new science of organic chemistry. All this new information was rapidly transmitted by European emigres, by an increasing number of medical and surgical periodicals, and by Americans studying abroad.

Because of its strategic location, Cleveland gradually became a rich and growing center of intellectual and cultural resources and attracted talent from both home and abroad. By 1890, with a population of more than 250,000, it had 4 medical schools, 3 medical societies, and 335 physicians, 25% of them homeopaths. The medical community was quick to assimilate new medical knowledge and techniques, and to modify its institutions accordingly. Among the influential figures in Cleveland medical education during this period was GUSTAV C. E. WEBER† (1828-1912), a German-born surgeon who came to Cleveland in 1856, having done postgraduate studies in Vienna, Amsterdam, and Paris. In 1864 he was one of the founders of St. Vincent de Paul Hospital (see SAINT VINCENT CHARITY HOSPITAL AND HEALTH CENTER), where he created a new medical school patterned after Bellevue Medical College in New York City, with student access to clinical as well as didactic teaching. Nearly 20 years later, from 1883-93, after the consolidation of several medical schools, Weber served as dean of the Medical Department of Western Reserve Univ., as the former Cleveland Medical College had been renamed. His successor, Isaac N. Himes (1834-95), who had also studied abroad and who later became Cleveland’s first hospital staff pathologist, raised the Medical Department’s faculty and curriculum to the most advanced standards. A number of its faculty members, such as WILLIAM THOMAS CORLETT†, a dermatologist, John P. Sawyer (d. 1945), a physiologist, and Christian Sihler (1848-1919), a histologist, as well as surgeons FRANK E. BUNTS† (1861-1928) and DUDLEY P. ALLEN† (1852-1915) had also studied abroad. The model for the medical department was the new Johns Hopkins Univ. School of Medicine (est. 1893) in Baltimore, MD. Cleveland search committees turned to Hopkins for new faculty members, such as the pathologist William Travis Howard, Jr. (1867-1953), and the gynecologist HUNTER ROBB†. In 1909, after Abraham Flexner completed his famous survey of American medical schools, he wrote to the president of WRU: “The Medical Department of Western Reserve Univ. is next to Johns Hopkins Univ. . . . the best in the country.”

No advances could have occurred if Cleveland hospitals had not become available for teaching and research. After the Civil War, every decade saw new hospitals established by private charitable corporations (see PHILANTHROPY) or churches (see RELIGION). Some were the progenitors of present-day institutions: the Cleveland City Hospital Assn., organized in 1866, gradually evolved into Lakeside Hospital, modeled on the Johns Hopkins Hospital (1889), and ultimately became a part of UNIVERSITY HOSPITALS CASE MEDICAL CENTER of Cleveland (1931); St. Vincent de Paul Hospital opened in 1865 and continued on its present site; the city infirmary evolved into the Cleveland City Hospital in 1891, which in 1956 became the Cleveland Metropolitan General Hospital, now called MetroHealth Medical Center (see CUYAHOGA COUNTY HOSPITAL SYSTEM (CCHS)). These 3 hospitals and the Huron Rd. Homeopathic Hospital were the first major teaching hospitals in the area. Medical care shifted from the home to the hospital, following the introduction of new diagnostic procedures such as x-ray, bacteriological and chemical laboratories, and aseptic surgical techniques. From the 1880s onward, more hospitals were founded to satisfy various needs, such as maternity, baby, and child care, and for specific populations, such as certain racial groups, women physicians (see WOMAN’S GENERAL HOSPITAL), and residents of SUBURBS. By 1943 there were around 30 hospitals in Cleveland with more than 8,000 beds, not including neighboring communities. The patients were no longer the poor and homeless, but people of every financial status. Physicians made fewer and fewer house calls.

As the causes of epidemic diseases became known, appropriate preventions or treatments were applied. A persistent problem had been typhoid fever–3,460 cases in Cleveland between 1912-26. When William Travis Howard, Jr., brought new pathological and bacteriological methods to Cleveland, he also became the city bacteriologist, a position created especially for him. Both he and his successor, ROGER G. PERKINS† (1912), suspected that the source of the typhoid bacilli was Lake Erie, from which the Cleveland water supply had been pumped since 1856 (see WATER SYSTEMSANITATION). After extensive research, the problem was finally corrected by Oct. 1925, with complete filtration and chlorination of the lake water. Infant mortality had also been very high, with deaths caused by diarrhea, dehydration, and malnutrition, especially among the offspring of immigrants from Southern and Eastern Europe (see IMMIGRATION AND MIGRATION). The Milk Fund Assn., founded in 1899 as a private charitable organization, and the Babies’ Dispensary & Hospital, incorporated in 1904 under the aegis of Edward Fitch Cushing (1862-1911) and HENRY JOHN GERSTENBERGER†, provided care for poor children and freed them from milkborne pathogens. In 1912 the city Health Department established a Bureau of Child Hygiene, which set up 12 dispensaries throughout the city and oversaw the milk production and distribution from its own dairy farm, aided by volunteers. Also, the VISITING NURSE ASSN. OF CLEVELAND brought medical supervision and care into the homes of the poor (see PUBLIC HEALTH). Pediatrics began to develop as a strong medical specialty. Gerstenberger, with postgraduate training in Berlin and Vienna, was appointed professor of pediatrics at the WRU School of Medicine in 1913, when the first separate department was established. He collaborated with a research chemist in developing SMA, a best-selling synthetic milk for infants, the income from which helped to create what became Rainbow Babies & Childrens Hospital (opened in 1925) of Univ. Hospitals. Cleveland became a major center for the training of pediatricians.

During World War I, GEORGE W. CRILE† organized a group of Lakeside Hospital physicians, surgeons, nurses, and enlisted men to serve in France (seeLAKESIDE UNIT, WORLD WAR I). (After WORLD WAR II broke out, on Christmas Eve 1941, the U.S. surgeon general invited the unit to be first again. A month later, the Clevelanders organized as the FOURTH GENERAL HOSPITAL.) While working together in France, surgeons Crile, his cousinWILLIAM E. LOWER†, and Frank E. Bunts recognized the advantages of group clinical practice; after returning, they invited internist JOHN PHILLIPS† to join them and established the CLEVELAND CLINIC FOUNDATION (1921). Crile had already distinguished himself nationally, by performing the first successful human blood transfusion in 1906, by his research on shock, and by his reputation for thyroid surgery. The Cleveland Clinic rapidly acquired a national and international reputation for specialization and quality care. Gases produced in a fire in 1929 (see CLEVELAND CLINIC DISASTER) caused many deaths, including that of founder John Phillips. The fire ultimately saved other lives worldwide, however, since it led to the development and use of nontoxic x-ray film.

After World War I, an affluent and growing Cleveland arranged to have a survey made of its hospitals to improve the quality of health care. The 1,082-page Cleveland Hospital & Health Survey (1920), one of the first in an American city, was carried out by an outside expert, Haven Emerson. Cleveland has pioneered in many other forms of cooperation and teamwork, such as the CLEVELAND HOSPITAL SERVICE ASSN. (est. 1934, later renamed BLUE CROSS OF NORTHEAST OHIO) and the Community Health Foundation (est. 1964), the first health-maintenance organization in the Middle West, nowKAISER PERMANENTE MEDICAL CARE PROGRAM. In addition, the Cleveland Health Education Museum (later the HEALTH MUSEUM), the first in the U.S., opened in 1940.

In the 1930s, innovators such as JOSEPH T. WEARN† at the WRU School of Medicine and Russell L. Haden at the Cleveland Clinic brought laboratory-oriented medical science to the forefront. Obstetricians from Cleveland hospitals, led by A. J. SKEEL† of SAINT LUKE’S MEDICAL CENTER, in 1932 formed the Cleveland Hospital Obstetric Society, which for 10 years collected data and analyzed the causes of maternal mortality, stimulating similar activity in other cities and influencing standards of the American College of Surgeons. Many cooperative medical events have occurred, such as the 1962 polio immunization campaign sponsored by the Cleveland Academy of Medicine and the Cuyahoga County Medical Foundation. On Sabin Oral Sundays, 2,400 physicians and other volunteers distributed sugar cubes containing polio vaccine and immunized more than 84% of the Cuyahoga County residents, the best record in the U.S. This success was facilitated by voluntary action, advertising, and public-relations expertise from the nonmedical community (seePHILANTHROPY). Earlier, in 1949, Cleveland radiologists had cooperated with the Academy of Medicine, the Antituberculosis Society, and the Greater Cleveland Hospital Assn. in a successful mass survey to detect tuberculosis among Greater Cleveland citizens.

One may finally ask, what are some of the unique contributions of Cleveland medicine? What, if any, major medical discoveries have been made? Medical “firsts” include Noah Worcester’s first American treatise on dermatology, A Synopsis of the Symptoms, Diagnosis, and Treatment of the More Common and Important Diseases of the Skin (Philadelphia, 1845); Abraham Metz’s first textbook on ophthalmology, The Anatomy and Histology of the Human Eye(Philadelphia, 1869); and Samuel W. Kelley’s first book on pediatric surgery, The Surgical Diseases of Children: A Modern Treatise on Pediatric Surgery(New York, 1909). On 8 Feb. 1896, 3 months to the day after Wilhelm Konrad Roentgen in Germany announced the discovery of x-rays, DAYTON C. MILLER†, a professor at Cleveland’s Case School of Applied Science, made the first x-rays in the U.S. He lectured 2 months later to the CLEVELAND MEDICAL SOCIETY. There were outstanding teachers, such as William Thomas Corlett, appointed in 1901 as one of the few American physicians to test the new syphilis remedy, Salvarsan, at Lakeside Hospital, CARL J. WIGGERS† (called the father of hemodynamics in the U.S.), the first editor ofCirculation Research, and TORALD H. SOLLMANN†, who in 1901 published the leading American textbook on pharmacology, which has gone through at least 8 editions. Endemic goiter has disappeared because of the research between 1915-20 of DAVID MARINE† and CARL H. LENHART† that showed that it was caused by iodine deficiency in the diet.

Since 1940 Cleveland’s major medical contributions have been in cardiovascular diseases and their treatment: the studies of angina pectoris carried out by Harold Feil and Mortimer Siegel at MT. SINAI MEDICAL CENTER and their pioneering work in electrocardiography; the experiments of HARRY GOLDBLATT† in hypertension; and the development of open-heart surgery by CLAUDE S. BECK† (who also gave the first course in cardiopulmonary resuscitation, later called CPR, 1950), and Jay Ankeney at Univ. Hospitals. In 1956 St. Vincent Charity Hospital opened the world’s first intensive-care unit devoted exclusively to heart surgery. Willem Kolff developed kidney dialysis techniques at the Cleveland Clinic, where he also started to develop the artificial heart, aided by research engineers at the NASA JOHN H. GLENN RESEARCH CENTER AT LEWIS FIELD. Cleveland Clinic became a “revascularization center” for coronary artery disease by means of bypass surgery, based on a technique developed by Ten Nobel laureates have been affiliated with the CWRU medical school, including Frederick C. Robbins, honored for his work with the polio virus. Other Cleveland contributions to medicine included pioneering work in gerontology, the activities of the CLEVELAND MEDICAL LIBRARY ASSN. (est. 1894), and the first and longest-running medical feature on a television news show, Dr. Theodore Castele’s segment of “Live on 5” (WEWS (Channel 5)), which began in 1975. In 1990 national attention focused on Univ. Hospitals researchers, headed by Dr. Roland W. Moskowitz, who traced osteoarthritis to a specific genetic defect; in 1993 Dr. Eric Topol concluded a 2-year study, the largest of its type, on the effects of the drug t-PA on heart attack patients. One can characterize medicine in Cleveland as equal and in many cases superior to that of other urban centers. In the 20th century, it has been especially distinguished by extensive institutional cooperation and outstanding private and community support.

Genevieve Miller

Case Western Reserve Univ. (emeritus)


Brown, Kent L., ed. Medicine in Cleveland and Cuyahoga County: 1810-1976 (1977).

Dittrick, Howard, comp. Pioneer Medicine in the Western Reserve (1932).

Waite, Frederick Clayton. Western Reserve University, Centennial History of the School of Medicine (1946).

Hospitals and Health Planning in Cleveland

From the Encyclopedia of Cleveland History

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HOSPITALS & HEALTH PLANNING. In the U.S., the hospital attained its “modern” institutional form by 1900-10, having passed through 3 more or less distinct stages. During the 19th century, the hospital began as an agency of social control and welfare, gradually became the principal provider of minimal medical care for the indigent and unfortunates of society, and emerged, ultimately, as the medical center for all classes of society, as well as the locus of medical training, research, and innovation. The institutional care of the sick originated in the incidental medical facilities provided for inmates of almshouses, jails, or, as in Cleveland, military posts. Here the first “hospital” was little more than a temporary barracks at FORT HUNTINGTON, situated near the mouth of the CUYAHOGA RIVER on Lake Erie. A log structure built in 1813, it furnished sparse accommodations to treat sick or injured soldiers of the War of 1812. DAVID LONG† was then the sole physician in the village of Cleveland. After this makeshift hospital closed in 1815, no other institution aided the sick until 1826, when the township erected a poorhouse adjacent to the ERIE ST. CEMETERY. In 1837, following the incorporation of Cleveland as a city, the poorhouse became the City Hospital. Not a hospital in the modern sense of the word, it, like other “hospitals” of the time, functioned chiefly to relieve pauperism.

In the second phase of their 19th-century development, hospitals became specifically medical institutions but limited their services to persons who could not afford the cost of treatment and convalescence in their homes. The opening of the U.S. MARINE HOSPITAL and ST. JOSEPH HOSPITAL in 1852 marked the beginning of this period in Cleveland. The U.S. Marine Hospital, financed and managed by the federal government, cared for merchant sailors and their families and for civilian and military personnel of the government. St. Joseph, operated by the SISTERS OF CHARITY OF ST. AUGUSTINE, briefly served a growing community of Irish laborers in the city. During this period, the city and state governments also reorganized their medical facilities for the poor. The City of Cleveland tore down City Hospital in 1851 and erected a new building, the City Infirmary, in 1855. The same year, the State of Ohio opened the Northern Ohio Lunatic Asylum, later known as CLEVELAND STATE HOSPITAL, in nearby NEWBURGH. Despite these improvements, most people still viewed hospitals as refuges for the infirm poor. With prevailing low standards of medical care, the hospitals of mid-19th century Cleveland were little better than the dreaded “pesthouses” of the past.

During the last third of the 19th century, hospitals were transformed by a combination of scientific and technical advances that together amounted to a revolution in medical thought and practice. The discovery of ether, chloroform, and nitrous oxide for anesthesia in the 1840s opened new realms for the surgeon, while the germ theory introduced by Louis Pasteur and applied to medical practice by Joseph Lister in the 1860s gave a clearer understanding of disease communication and prevention. These innovations could be implemented most successfully in the controlled environment of the hospital, and medical practice shifted progressively from homes to hospitals. In Cleveland, this transfer accelerated in the closing years of the 19th century. At mid-century, there were only 3 hospitals in Cleveland. Two decades later, 1870-75, 7 were in operation: 3 under municipal, state, and federal management, 2 maintained by Catholic religious orders (see CATHOLICS, ROMAN), and 2 voluntary hospitals under the control of lay trustees. By 1890-96 this number had more than doubled, including 8 hospitals under the care of religious denominations, 5 voluntary institutions, and the 3 existing public facilities. In addition, the Cleveland medical scene was also populated by a growing assortment of dispensaries opened by medical colleges in the city, small private hospitals operated as business ventures by enterprising doctors, and several private sanatoriums for the care of patients with emotional or drug- and alcohol-related health problems.

Hospitals ceased to be merely dormitories for the destitute. The first hospital designed to serve medical needs and not just to perform custodial functions was St. Vincent de Paul Hospital (1865, see SAINT VINCENT CHARITY HOSPITAL AND HEALTH CENTER). Its central section housed offices, a chapel, a pharmacy, and staff apartments, with kitchen, dining, and storerooms in the basement. This section was flanked by 2 wings, each occupied by separate male and female wards for 56 charity cases on the ground floor, while the second floor of both wings was divided into private rooms for 24 paying patients. Absence of separate surgical facilities was remedied by construction in 1872 of an amphitheater–the first in any hospital in Cleveland. This general pattern prevailed in the design of other local hospitals until the end of the 19th century. The first major change in the design of Cleveland hospitals came with the construction of Lakeside Hospital (see UNIVERSITY HOSPITALS CASE MEDICAL CENTER). Like many hospitals in the city, Lakeside began its institutional life in a private residence converted to accommodate patient beds. Between 1876-96, Lakeside occupied the U.S. Marine Hospital; it was finally compelled to erect a new building upon expiration of its lease. In 1891 and 1895, trustees visited major hospitals in metropolitan centers east of the Mississippi and subsequently adopted a pavilion or “cottage” plan modeled on Johns Hopkins Hospital (1885) in Baltimore, then the most respected teaching hospital in America. The pavilion plan of the new Lakeside Hospital, located at E. 12th St. and Lakeside Ave., offered the ventilation and drainage deemed essential for proper SANITATION. Central administrative, kitchen, and laundry services were housed in separate buildings connected to wards, surgical buildings, and dispensary and nurses’ quarters by long corridors. The only structure that stood apart from the whole was the “autopsy building,” which accommodated pathology and clinical microscopy laboratories after 1901. The overall layout of the hospital was dictated by the new appreciation of the role that germs played in disease, with isolation and ventilation the most important features of any hospital plan.

Hospitals in Cleveland first became educational institutions, helping to train physicians, when Dr. GUSTAV WEBER† founded Charity Hospital Medical College in 1864. Weber, a prominent surgeon, launched the new school with the full cooperation of St. Vincent de Paul Hospital. Each party benefited: Weber enjoyed privileged access to cases for clinical instruction, while St. Vincent engaged a competent medical staff at little or no cost. Although the college closed in 1870, St. Vincent had set a local precedent for close cooperation between hospitals and medical schools. The first university hospital in Cleveland came into being in 1897-98 with the opening of Lakeside Hospital. Since 1869, Lakeside had given WRU teaching privileges, shared with the Wooster Univ. Medical Department (1870-84): each school held its clinical sessions at different seasons of the year. After 1884, WRU acquired exclusive control of teaching privileges at Lakeside. Beginning in 1898, the WRU Medical Department also nominated resident staff and furnished visiting physicians and surgeons. The first university hospital in Cleveland, Lakeside ranked among the first 10 such institutions in the U.S.

Hospitals constituted the sole training ground for NURSING in Cleveland from 1884, when HURON RD. HOSPITAL opened the first training school for nurses in Ohio, until the establishment of a nursing degree by WRU in 1921. In the interval, several Cleveland hospitals, most notably Cleveland General (now SAINT LUKE’S MEDICAL CENTER), Lakeside, and St. Vincent, created their own schools. In the early years of these programs, young women received in-service training in “practical nursing” and little formal instruction. Only at Lakeside, through the efforts of national expert ISABEL HAMPTON ROBB†, did nursing education emphasize instruction in the theoretical and scientific side of nursing as well as the practical. Scientific medicine, particularly the laboratory-based specialties of pathology, bacteriology, and physiology, entered the institutional setting of Cleveland hospitals after 1890. The most notable example of this influence was the establishment of a bacteriology laboratory at City Hospital. Dr. William Travis Howard, a young pathologist trained at Johns Hopkins and professor of pathology at WRU, headed the laboratory and initiated scientific postmortem examinations at City Hospital.

By the turn of the century, many hospitals in Cleveland attracted a more affluent class of patients. Some hospitals actively courted paying patients by offering comfortable, if not luxurious, accommodations. While no Cleveland hospitals abandoned their original charitable obligations, the poor increasingly patronized out-patient dispensaries operated by the medical departments of WRU, the Cleveland College of Physicians & Surgeons (Ohio Wesleyan Univ.), and the CLEVELAND HOMEOPATHIC HOSPITAL College. Following expansion and modernization in 1889, City Hospital undertook a greater role in providing medical care for the indigent throughout the city. Later, it also erected a tuberculosis sanatorium and a hospital for contagious diseases, allowing other local hospitals to present themselves as “safe” havens for sick persons of all social classes, free from dreaded communicable illnesses. In addition to improving the attractiveness and safety of private rooms for paying patients, some hospitals permitted nonstaff doctors to visit and treat patients in the hospital setting. Lakeside Hospital, for example, relaxed its rules to accommodate physicians who brought private paying patients, opened a specially designated operating room for use by physicians and surgeons not officially affiliated with the institution, and appointed a resident staff officer for patients of such physicians and surgeons.

The principal institutional developments in Cleveland hospitals between 1910-50 included the emergence of the group-practice hospital, the move of several hospitals to the SUBURBS, and the advent of health insurance programs. The CLEVELAND CLINIC FOUNDATION, incorporated in 1921, was the first and by far the most successful group-practice hospital in Cleveland. Its founders, particularly Drs. GEORGE W. CRILE†, FRANK E. BUNTS†, andWILLIAM E. LOWER†, derived their inspiration from the example of the Mayo Clinic and from experience as members of the LAKESIDE UNIT, WORLD WAR I. They combined the practice of surgery and medicine with new diagnostic procedures and ongoing medical research. Organized as a not-for-profit foundation staffed by salaried physicians, the Cleveland Clinic overcame the onus heaped on group clinics by individualistic private practitioners who perceived a threat to the prevailing free-market economy in American medicine.

By 1920, as noted in the Cleveland Hospital and Health Survey, local hospitals could be categorized according to the strength of their community orientation. One group, comprising FAIRVIEW HOSPITALST. JOHN HOSPITAL, Glenville Hospital, Lutheran Hospital (see LUTHERAN MEDICAL CENTER), Provident Hospital, Grace Hospital (see GRACE HOSPITAL ASSN.), St. Ann’s Hospital (see SAINT ANN FOUNDATION), and ST. ALEXIS HOSPITAL MEDICAL CENTER, drew the majority of their cases from their own vicinity. A second group, which included Huron Road, Lakeside, City, Mt. Sinai (see MT. SINAI MEDICAL CENTER), St. Luke’s, and St. Vincent’s, no longer served just their immediate neighborhoods but drew patients from all regions of Cleveland. Together these last 6 hospitals contained 60% (1,812 beds) of the total capacity (3,088 beds) of the 20 hospitals belonging to the Cleveland Hospital Council (see CLEVELAND HOSPITAL ASSN.) in 1920. Several hospitals in this second group led the move toward the suburbs between 1915-35. They were prompted by the need to renew aging physical plants and lured by locations closer to a middle-class clientele better able to pay for hospital care. Mt. Sinai initiated this relocation in 1916, moving to the present UNIVERSITY CIRCLE area. It was followed by WOMAN’S GENERAL HOSPITAL, Lakeside, Maternity (later MacDonald), and Rainbow hospitals, which had all opened new buildings adjacent to WRU by 1931. This first wave of urban flight culminated with the relocation of St. Luke’s on Shaker Boulevard (1927) and Huron Road in EAST CLEVELAND (1935).

During the Depression, Cleveland hospitals confronted economic uncertainties by turning to a group medical insurance plan now known as Blue Cross (seeBLUE CROSS OF NORTHEAST OHIO). Under early versions of Blue Cross, first instituted in Dallas, TX, in 1929, individual hospitals concluded contracts with subscribing groups to provide hospitalization in return for a set annual fee. In Cleveland, no single hospital plan took hold. Instead, in 1934 the Cleveland Hospital Council initiated a citywide plan in which cooperating hospitals agreed to provide service on a prepaid basis. By this arrangement, Blue Cross enabled voluntary hospitals in Cleveland to maintain a steady level of bed occupancy while also preventing competition for patients among member hospitals. In 1938 Cleveland’s Blue Cross became the first prepayment plan in the U.S. to reimburse hospitals on the basis of cost, a move made possible by the growth of its subscriber group to over 100,000. Over the following decades, Blue Cross emerged as the dominant form of hospitalization insurance in Greater Cleveland, covering 70% of Cuyahoga County hospital patients on the eve of Medicare in 1965.

The economic stability provided by Blue Cross, combined with advances in surgery and diagnostic technologies, encouraged considerable expansion of hospitals in Cleveland following World War II. The number of beds in general medical-surgical and maternity hospitals in Cuyahoga County grew 20% between 1952-60 (from 5,197 to 6,636) and 30% between 1960-75 (from 6,636 to 9,666). The enlargement of existing facilities and the creation of new hospitals (PARMA COMMUNITY GENERAL HOSPITALBRENTWOOD HOSPITALFOREST CITY HOSPITAL, and SUBURBAN COMMUNITY HOSPITAL) were financed by bond issues in the case of publicly supported hospitals and by individual, corporate, and foundation contributions and reserve funds for depreciation in the case of voluntary hospitals. Federal grants, available chiefly through the provisions of the Hospital Survey & Construction Act (1946, known as the Hill-Burton Act in honor of its legislative sponsors, Senator Harold Burton of Ohio and Senator Lister Hill of Alabama) [PL 79-725, Title VI of the Public Health Service Act], played only a supplementary role in hospital growth in Cleveland and Cuyahoga County before the mid-1960s. However, federal assistance in the form of Medicare and Medicaid did become an important source of general revenue for Cleveland hospitals after 1965; by 1980 Medicare and Medicaid constituted 41% of hospital patient revenues in Cleveland and 38% in the suburban sections of the county. At the same time that hospitals underwent physical expansion, population growth slowed and then declined in Cleveland and the vicinity. Between 1960-70, population in Cuyahoga County grew only 4% (from 1,647,895 to 1,721,300), then declined 7% between 1970-80 (from 1,721,300 to 1,499,167). The net result was that the county, and especially the City of Cleveland, had a surplus of hospital beds, which often fell below the 85% occupancy rate considered optimal for voluntary hospitals. Low occupancy, together with the financial burden of construction or renovation and the cost of maintaining specialized services, led to a steady increase in per diem hospital costs to patients or their insurers. The average cost per patient day in Cleveland hospitals rose from $28.40 in 1957 to $268 in 1980. The hospitals of Cleveland and related agencies confronted spiraling health costs in a number of ways, especially with regional hospital and health planning, the imposition of cost ceilings by third-party insurers (Blue Cross and others), and the creation of health maintenance organizations (HMOs).

Regional hospital planning in Cleveland began with the formation of the Cleveland Hospital Council in 1916. This organization engaged Haven Emerson, health commissioner of New York City, to investigate and report on the institutional network responsible for health care in Cleveland. His findings were presented in the Cleveland Hospital and Health Survey (1920), a landmark study in the field. However, this publication did not result in any coherent program of health care planning; area hospitals continued to pursue separate institutional goals without coordination. The next major attempt to institute regional planning came in 1941, when HAROLD BURTON†, mayor of Cleveland, appointed the Joint Hospital Committee. Created to consider the anticipated resurgence of hospital construction following World War II, the committee included representatives of the city of Cleveland, the Cleveland Welfare Federation, and the Cleveland Hospital Council. The role of this local body was soon effectively eclipsed by state agencies, which were given principal health-planning responsibilities under the Hospital Construction & Survey Act in 1946. The concept of regional planning was not revived until 1966, when the Comprehensive Health Planning Act returned planning responsibilities to local agencies. In northeast Ohio this role was assumed by the Comprehensive Health Planning Agency (CHPA), which served Cuyahoga, Lake, Geauga, and Medina counties. The CHPA, later known as theMETROPOLITAN HEALTH PLANNING CORP., commissioned studies of existing health-care facilities, determined the strengths and weaknesses of the region’s hospital system, and assessed the validity of requests by area hospitals for expansion of facilities, particularly regarding state and federal funding for new construction. Although the MHPC initially acted in a consultative capacity, its designation by the federal government as a Health Systems Agency increased its influence and power in regional health planning.

Imposition of cost ceilings upon Cleveland-area hospitals has come from 2 principal sources since the advent of Medicare in 1965. At first, Blue Cross reimbursed hospitals on the basis of cost instead of a schedule of negotiated rates. This arrangement was altered by state legislation in 1972 and 1976 that prohibited hospitals from controlling the boards of Ohio Blue Cross plans and that admonished such plans to eliminate waste and unnecessary services. In 1987 Blue Cross and Blue Shield of Ohio, along with other state health insurers, won further leverage in their efforts to contain costs with passage of the state Hospital Insurance Reform Act, which gave them the right to negotiate rates with hospitals. A second, more far-reaching challenge to hospital-determined costs for medical care came in Oct. 1983, when Medicare began the transition to a payment schedule based on diagnosis-related groups (DRGs), instead of actual costs incurred for hospital care. The intent of the DRG program was to curb inflationary trends by basing payment on the characteristics of the patient’s illness, rather than on the demands of hospitals.

It is still too soon to assess all the consequences of these changes in hospital administration and finance, but one trend is already apparent: the shift to health maintenance organizations (HMOs) as a means for hospitals to introduce or cooperate with a prepaid group plan for payment of medical costs. HMOs were preceded by the prepaid group practice, with origins in the health-care programs of INDUSTRY and RAILROADS. These employers engaged profit-making firms of physicians and surgeons to provide medical services at clinics and small hospitals financed by industrialists’ subscriptions and workers’ salary deductions. Corporate sponsorship of such prepaid programs began in America ca. 1910 in the Pacific Northwest and did not spread to other regions until 1930. In Cleveland, employers did not have to resort to this form of “welfare capitalism,” since many hospitals readily accommodated the industrial workforce under Blue Cross plans. Organized labor, however, saw the desirability of a prepaid group plan for workers, and in 1964 labor unions in Cleveland formed the Community Health Foundation. This HMO provided routine medical care in the offices of several private physicians and hospital care in cooperating local institutions. In 1969 the Community Health Foundation joined with the KAISER PERMANENTE MEDICAL CARE PROGRAM to form the Kaiser Community Health Foundation. By 1974 Kaiser Permanente comprised 3 separate hospital facilities in Cleveland, and by 1985 the system had become the largest HMO in the U.S., encompassing some 4.6 million members in 9 geographic regions.

In 1970 there were only 33 HMOs nationwide; by 1977 the number had grown to 183, with 6.85 million persons enrolled; by 1985 there were 323 HMOs in the U.S., with a total enrollment of 15 million. In Cleveland and the immediate vicinity of Cuyahoga County, the number of HMOs increased from 1 in 1970 (Kaiser-Permanente) to 8 in 1985.

In the 1990s, continued competition for patients and the debate over national and state health care reform gave further impetus to the shift to HMOs and set off a wave of mergers, acquisitions and affiliations. The trend in this activity was toward the vertical integration of the region’s health care industry into large, self-contained units consisting of insurers, physicians, hospitals and out-patient facilities that could offer a complete health care package to employers or groups of employers. By 1995, three prominent groups had emerged: Blue Cross and Blue Shield of Ohio, which, in addition to its health insurance and Super Blue HMO, had controlling interest in a joint venture with the four hospitals in the MERIDIA HEALTH SYSTEM, and affiliations with St. Luke’s Medical Center and Riverside Hospital in Toledo, OH; the University Hospitals Health System, which had affiliations with four hospitals and offered a broad range of outpatient services as well as the Qualchoice health insurance plan; and the Health Cleveland Network, consisting of 11 hospitals, including the Cleveland Clinic and the MetroHealth Medical Center.

By 1995, however, the Clinton administration’s plan for managed care was dead, leaving prospects for national reform uncertain at best, and Governor Voinovich’s proposal to move 1.4 million poor Ohioans into a network of HMOs paid for by Medicaid faced critical funding problems as the U.S. Congress considered turning Medicaid into a block grant program. Moreover, despite the frenzy of mergers, acquisitions and affiliations, the area’s health care providers had not yet dealt with the underlying problem of the over-capacity of hospital facilities. Given the uncertainty of governmental health care reform, it was not clear whether the vertical integration of the region’s health care system represented a step toward a managed care system, or protection of the traditional fee-for-service payment structure under the shelter of a privately operated system of prepayment.

James Edmonson

Dittrick Museum of Medical History

Teaching Cleveland Digital